According to the Centers for Disease Control, nearly 20% of children and teens are considered obese. Research shows it can have a dramatic impact on a variety of health conditions, including arthritis, heart conditions and other metabolic problems, and the American Academy of Pediatrics now recommends early and intensive treatment to combat obesity. Over the last four years, Shriners Children's St. Louis researchers have been working to develop a new way to prevent the effects of childhood obesity.

A new study from Karolinska Institutet in Sweden and the Chinese Academy of Medical Sciences has identified an RNA molecule that is important for skin wound healing. The research, published in Nature Communications, may have implications for the treatment of hard-to-heal wounds.

The study focuses on the molecular processes in wound healing that regulate the transition from inflammation - a critical defence mechanism - to a proliferative phase, where new cells form to repair damaged tissue.

Imagine a world where your own immune cells are transformed into cancer-fighting superheroes. This is the promise of CAR-T cell therapy, a groundbreaking treatment that’s already saving lives.

In this therapy, patients' own immune cells are collected, genetically engineered so that they specifically target cancer cells, then returned to the body. The result is a potent new option for battling blood cancers. However, as with any superhero journey, the process of harnessing this incredible power comes with its own set of challenges.

Some proteins in the human body are easy to block with a drug; they have an obvious spot in their structure where a drug can fit, like a key in a lock. But other proteins are more difficult to target, with no clear drug-binding sites.

To design a drug that blocks a cancer-related protein, Scripps Research scientists took a hint from the protein's paralog, or "twin."

Glioblastoma is one of the most serious brain diseases known. More than 45% of brain cancers are gliomas. Only half of glioblastoma patients respond to the FDA-approved chemotherapy Temozolomide (TMZ). Even for those patients, the cancer cells quickly evolve resistance. Most patients pass away within 12 to 16 months after diagnosis, and few make it beyond five years.

Now a glimmer of hope for patients comes from an unlikely place: Jackson Hole, Wyoming, where scientists at the non-profit Brain Chemistry Labs have been studying molecules found in violets.

More than one-third of adults in the United States have metabolic syndrome, a cluster of conditions that significantly raise a person's risk of heart disease, stroke, and type 2 diabetes. These conditions include high blood pressure, elevated blood sugar, excess abdominal fat, and abnormal cholesterol levels.

In a new clinical trial, researchers at the Salk Institute and University of California San Diego School of Medicine found that time-restricted eating - also known as intermittent fasting - could offer significant health benefits to adults with metabolic syndrome.

In 2022, nearly 619,000 global deaths due to malaria were caused by Plasmodium falciparum, the most virulent, prevalent, and deadly human malaria parasite. For decades, the parasite's resistance to all antimalarial drugs has posed a big challenge for researchers working to stop the spread of the disease.

A team led by scientists at UC Riverside, UC Irvine, and Yale School of Medicine has now designed a new drug against malaria and identified its mechanism of action.