Breaking WORLD PHARMA NEWS

Candidate breast cancer drug overloads tumors with "surge" of toxic lipids

An experimental drug targeting triple-negative breast cancer overwhelms cancer cells with toxic fats, according to new tests on human-derived tumors in mice. Triple-negative breast cancer lacks three common drug targets, making it one of the most aggressive forms of the disease.

The compound, known as DH20931, appears to push cancer cells past their limits by triggering a surge in fat-like molecules called ceramides.

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Fighting oral cancer with bioengineered chewing gum

Researchers led by Henry Daniell of the School of Dental Medicine have shown that extracts from bioengineered chewing gum reduce the levels of three microbes known to be associated with head and neck squamous cell cancer (HNSCC), paving the way for more effective and affordable therapies. Their findings are published in Scientific Reports.

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Millions suffering needlessly with curable hepatitis C

Millions of Americans are still battling potentially deadly hepatitis C even though they could be cured with antiviral drugs they are not receiving, a new analysis reveals.

University of Virginia School of Medicine researcher Sanjay Kishore, MD, and colleagues at Mass General Brigham looked at prescribing trends for the drugs, known as direct-acting antivirals. They found that prescriptions rose rapidly when the drugs were first introduced in 2013, then peaked in 2015.

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Targeting the yin and yang of macrophages to strengthen cancer vaccines and anti-tumor immunity

Macrophages, key regulators of tissue health and immune defense, are among the most abundant immune cells in solid tumors. Their role in cancer has been difficult to define because even closely related macrophage populations can have very different, and sometimes opposing, functions.

Funded by the National Institutes of Health’s National Heart, Lung, and Blood Institute, researchers at Geisel School of Medicine, led by principal investigator Claudia Jakubzick, PhD, professor of microbiology and immunology,

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New knowledge about mobile proteins linked to childhood cancer

Researchers at Linköping University show how two important cancer-related proteins can be prevented from collaborating with each other. The discovery shows the way towards future medications to combat e.g. neuroblastoma in children. Their study has been published in the journal Nature Communications.

“Today we can cure many cases of childhood cancer that were incurable ten years ago. But there’s still an important group of childhood tumours that evade cure.

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3D experimental system to evaluate candidate drugs against glioma

A three-dimensional experimental system has been developed to study the response to drugs in low-grade glioma, a tumor of the central nervous system that often occurs in children. The project, developed by the University of Trento, Bambino Gesù Children's Hospital and Sapienza University of Rome, is a breakthrough in the study, understanding and treatment of the disease.

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New drug combination doubles down on Alzheimer's treatments

A new study finds that combining the current medications for Alzheimer’s disease with small molecules derived from micronutrients found in grapes, berries, peanuts and turmeric is a safer and more effective way to treat the disease.

Individuals with Alzheimer’s have a buildup of toxic amyloid proteins in the brain. Researchers from the School of Pharmacy at the University of Waterloo combined amyloid-destroying small molecules with anti-amyloid antibodies that are already used in Alzheimer’s treatment.

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A small molecule drug candidate fully restores survival in a lethal mouse model of a rare kidney stone disease

Scientists at the Buck Institute for Research on Aging have shown that an orally administered small molecule, N-propargylglycine (N-PPG), can completely prevent the formation of calcium oxalate kidney stones, protect against kidney failure, and fully restore normal survival in a mouse model of Primary Hyperoxaluria Type 2 (PH2), a rare and currently untreatable genetic disorder that causes progressive kidney failure in infants and young adults.

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Scientists discover the antibacterial potential of ‘hero’ Korean skincare ingredient

Fans of Korean skincare may be familiar with ‘hero ingredient’ Madecassic acid for its skin-soothing properties, but researchers at the University of Kent have revealed its greater potential for use in the battle against antibiotic resistance.

Using a combination of computational screening and laboratory experiments, scientists in the School of Natural Sciences together with those at University College London (UCL) have demonstrated how this natural chemical from the common Asian herb Centella asiatica, is an effective antibacterial drug.

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Bristol Myers Squibb evolves and expands Standing in the Gaap to advance more equitable care in multiple myeloma

Bristol Myers Squibb (NYSE: BMY), a global leader in oncology, announced the evolution of Standing in the Gaap, a long-running program designed to help address persistent gaps in care for people living with multiple myeloma (MM) in medically underserved communities. Building on a decade of sustained commitment, BMS is reinforcing its focus on equitable access to multiple myeloma education, resources, and community-driven solutions by expanding the program to reach more patients and care partners.

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