Sanofi (EURONEXT: SAN and NYSE: SNY) announced that data from eight compounds in the company's robust oncology portfolio will be showcased in more than 100 abstracts at the 47th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, June 3-7, 2011.
Data presentations highlight the Sanofi Oncology pipeline in both solid tumors and hematologic malignancies. New research from early through late stage development will be reported, including data on cabazitaxel, docetaxel and oxaliplatin, as well as on investigational compounds iniparib and semuloparin.
"Sanofi fully supports this year's ASCO Presidential Theme - Patients, Pathways and Progress. Our connection to the patient inspires us to partner with leading experts to exchange ideas that will help us discover innovative solutions to improve patient outcomes," said Debasish Roychowdhury, MD, Senior Vice President and Head of Global Oncology Division. "Sanofi is committed to ASCO and its mission."
About Iniparib (BSI-201)
BSI-201 is a novel investigational oncology agent that is in Phase III trials for patients with
squamous non-small cell lung cancer, as well as in Phase II trials for patients with breast, lung and other cancers. Iniparib is the United States Adopted Name (USAN) for BSI-201.
About Cabazitaxel
Cabazitaxel is a semi-synthetic taxane and works differently than docetaxel and paclitaxel. An
antineoplastic agent, it acts by disrupting the microtubular network in cells. It binds to tubulin and promotes the assembly of tubulin into microtubules while simultaneously inhibiting their disassembly. This leads to the stabilization of microtubules. Cabazitaxel demonstrated a broad spectrum of antitumor activity against advanced solid tumours xenografted in mice. Cabazitaxel is active in docetaxel sensitive tumors. In addition, cabazitaxel demonstrated activity in tumour models insensitive to chemotherapy, including docetaxel.
About Semuloparin
Semuloparin is an investigational, selectively engineered anticoagulant that belongs to the ultra-lowmolecular-weight heparin (ULMWH) class. Semuloparin has a novel anti-thrombotic profile resulting
from an enriched antithrombin binding site and high-activity against factor Xa and residual activity
against factor IIa. A large phase III clinical study (SAVE ONCO study) investigated semuloparin in
cancer patients receiving chemotherapy that has been completed. The SAVE ONCO study assessed the efficacy and safety of semuloparin for the prevention of symptomatic VTE, Pulmonary Embolism and VTE related death in cancer patients receiving chemotherapy. There is currently no product registered in this indication.
About BiPar Sciences
BiPar Sciences is a biopharmaceutical organization dedicated to pioneering novel tumor-selective
therapies designed to address urgent unmet needs of cancer patients. Located in South San
Francisco, California, BiPar is a wholly owned subsidiary of Sanofi.
About Sanofi Oncology
Based in Cambridge, Massachusetts, and Vitry, France, Sanofi Oncology is translating science into
effective cancer therapeutics to address unmet medical needs for patients with cancer. Starting with
a deep understanding of the mechanisms by which cancer develops, grows and spreads, the
company employs innovative approaches in drug discovery, clinical development and partnerships
to bring the right medicines to the right patients with the goal of helping cancer patients live
healthier and longer lives. Sanofi Oncology is committed to the pursuit of science and innovative cancer therapies. We believe in partnership with leading experts, and combining that expertise with our own internal scientific strength and heritage. There are currently more than 10 compounds in clinical development including small molecules and biological agents.
About Sanofi
Sanofi, a global and diversified healthcare leader, discovers, develops and distributes therapeutic solutions focused on patients' needs. Sanofi has core strengths in the field of healthcare with seven growth platforms: diabetes solutions, human vaccines, innovative drugs, rare diseases, consumer healthcare, emerging markets and animal health. Sanofi is listed in Paris (EURONEXT: SAN) and in New York (NYSE: SNY).