Computer predicted life saving benefit of Baricitinib for ventilated COVID patients
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- Category: Research
Critically ill COVID-19 patients on a mechanical ventilator or extracorporeal membrane oxygenation (ECMO) lived more often when randomized to receive baricitinib. Doctors call this drug 'bari,' and receiving the pill once a day for up to 14 days yielded one of the largest a survival advantages seen yet in the COVID pandemic, according to a study published in The Lancet Respiratory Medicine.
Three exposures to spike protein allow people to develop broad antibody immunity - also against Omicron
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- Category: Research
Scientists from Ludwig-Maximilians-Universitaet (LMU) in Munich, Helmholtz Munich, and Technical University of Munich have shown that the immune system is capable of neutralizing even Omicron after a total of three exposures to the viral spike protein.
Since the beginning of the COVID-19 pandemic, SARS-CoV-2 has continued to evolve, with new variants of concern (VoCs) spreading rapidly.
Study finds COVID-19 less severe in fully vaccinated
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The clinical and imaging characteristics of COVID-19 breakthrough infections in fully vaccinated patients tend to be milder than those of partially vaccinated or unvaccinated patients, according to a new multicenter study published in the journal Radiology.
The number of confirmed COVID-19 cases worldwide now exceeds 270 million with an overall mortality rate of approximately 2%.
The key to a powerful antibiotic's formation now clear
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A powerful class of antibiotics called carbapenems can circumvent antibiotic resistance thanks to a particular chain of atoms in their structure. Now, a team of researchers from Penn State and Johns Hopkins University have imaged an enzyme involved in the creation of this chain to better understand how it forms - and perhaps replicate the process to improve future antibiotics. A paper describing the process appears in the journal Nature.
Compound in the herb rosemary may be useful against COVID-19 and other inflammatory diseases
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A team co-led by scientists at Scripps Research has found evidence that a compound contained in the medicinal and culinary herb rosemary could be a two-pronged weapon against the SARS-CoV-2 coronavirus that causes COVID-19.
The scientists, in experiments described in a paper published January 6, 2022 in the journal Antioxidants, found that the compound, carnosic acid, can block the interaction between the SARS-CoV-2 outer "spike" protein and the receptor protein, ACE2, which the virus uses to gain entry to cells.
Current COVID-19 vaccines induce robust cellular immunity against Omicron variant
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- Category: Research
A highly mutated version of SARS-CoV-2, the virus that causes COVID-19, the Omicron variant has been shown to cause breakthrough infections among the vaccinated thanks to its ability to evade the virus-killing neutralizing antibodies that the body makes in response to getting vaccinated.
Parental vaccination against coronavirus offers substantial protection to children as well
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The Clalit Research Institute, in collaboration with researchers from Harvard University and Tel-Aviv University, analyzed one of the world’s largest integrated health record databases to examine the indirect protection provided to unvaccinated children through parental vaccination with the BNT162b2 (Pfizer) vaccine.
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