Glioblastoma is one of the most serious brain diseases known. More than 45% of brain cancers are gliomas. Only half of glioblastoma patients respond to the FDA-approved chemotherapy Temozolomide (TMZ). Even for those patients, the cancer cells quickly evolve resistance. Most patients pass away within 12 to 16 months after diagnosis, and few make it beyond five years.

Now a glimmer of hope for patients comes from an unlikely place: Jackson Hole, Wyoming, where scientists at the non-profit Brain Chemistry Labs have been studying molecules found in violets.

More than one-third of adults in the United States have metabolic syndrome, a cluster of conditions that significantly raise a person's risk of heart disease, stroke, and type 2 diabetes. These conditions include high blood pressure, elevated blood sugar, excess abdominal fat, and abnormal cholesterol levels.

In a new clinical trial, researchers at the Salk Institute and University of California San Diego School of Medicine found that time-restricted eating - also known as intermittent fasting - could offer significant health benefits to adults with metabolic syndrome.

In 2022, nearly 619,000 global deaths due to malaria were caused by Plasmodium falciparum, the most virulent, prevalent, and deadly human malaria parasite. For decades, the parasite's resistance to all antimalarial drugs has posed a big challenge for researchers working to stop the spread of the disease.

A team led by scientists at UC Riverside, UC Irvine, and Yale School of Medicine has now designed a new drug against malaria and identified its mechanism of action.

A University of Missouri researcher has created a computer program that can unravel the mysteries of how proteins work together - giving scientists valuable insights to better prevent, diagnose and treat cancer and other diseases.

Jianlin "Jack" Cheng from Mizzou's College of Engineering and his student, Nabin Giri, have developed a tool called Cryo2Struct that uses artificial intelligence (AI) to build the three-dimensional atomic structure of large protein complexes, work recently published in Nature Communications.

Women in the UK, and elsewhere, are still missing out on vital treatment for their No 1 killer - cardiovascular disease - despite significant progress in the medical management of heart disease and stroke, concludes a consensus statement published online in the journal Heart.

They continue to be underdiagnosed, undertreated, and underrepresented in clinical trials in all areas of cardiovascular disease, says the statement.

Researchers from the Food Packaging Forum identify and discuss nearly 200 potential breast carcinogens that have been detected in food contact materials (FCMs) on the market. Many nations have food contact material legislation intended to protect citizens from hazardous chemicals, often specifically by regulating genotoxic carcinogens. As cancer is one of the few health endpoints specifically targeted in FCM regulations and testing, carcinogenic chemicals in food packaging and other food contact materials and articles should not be commonplace.

Some triptans are a more effective treatment for acute migraines than newer, more expensive drugs, finds an analysis of the latest evidence published by The BMJ.

Triptans work by narrowing blood vessels in the brain and preventing the release of chemicals that cause pain and inflammation.

The findings show that four triptans - eletriptan, rizatriptan, sumatriptan, and zolmitriptan - were better at relieving migraine pain than the recently marketed and more expensive drugs lasmiditan, rimegepant, and ubrogepant, which were comparable to paracetamol and most anti-inflammatory painkillers (NSAIDs).