Dangerous drug interactions uncovered with data science
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Researchers at Columbia University Medical Center and the Data Science Institute at Columbia University have uncovered a potentially dangerous drug interaction using data science. Their findings were published in the latest issue of the Journal of the American College of Cardiology. Safe when taken on their own, some prescription drugs become deadly when combined. Many of these interactions are well known, but others remain hidden to doctors, drug companies, and patients.
First human clinical trial for nicotinamide riboside
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In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage. Studies in mice have shown that boosting the levels of this cell metabolite - known as NAD+ - can produce multiple health benefits,
Research details industry payments to dermatologists
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Connections between industry and clinicians exist and a new study published online by JAMA Dermatology used publicly available data to analyze the nature and extent of industry payments to dermatologists. Marie Leger, M.D., Ph.D., of the Weill Cornell Medicine, New York, and coauthors used the Centers for Medicare and Medicaid Services (CMS) Sunshine Act Open Payment database, which records payments to physicians from manufacturers or group-purchasing organizations that make products reimbursed by a government-run health program.
Maximum human lifespan has already been reached
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A study published online today in Nature by Albert Einstein College of Medicine scientists suggests that it may not be possible to extend the human life span beyond the ages already attained by the oldest people on record. Since the 19th century, average life expectancy has risen almost continuously thanks to improvements in public health, diet, the environment and other areas.
Study explains how an intestinal microbe protects against other, more dangerous bacteria
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Antibiotics save millions of lives. But their tendency to kill helpful and harmful bacteria alike, coupled with the growing problem of antibiotic resistance, means that they are not without their downside. Probiotics consisting of beneficial microorganisms, meanwhile, have the potential to deliver the benefits of antibiotics minus the pitfalls. Yet up until now, evidence of their efficacy has been largely anecdotal, their mechanisms of action poorly understood.
Alcohol shown to act in same way as rapid antidepressants
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Can having a few drinks help people with clinical depression feel better? Yes. At least in terms of biochemistry. In a study published in the current issue of the journal Nature Communications, researchers found that alcohol produces the same neural and molecular changes as drugs that have proven to be rapidly effective antidepressants.
Component of red wine, grapes can help to reduce inflammation
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A component of red wine and grapes can help control inflammation induced by a bacterial pathogen that is linked to upper respiratory tract inflammatory diseases such as asthma, chronic obstructive pulmonary diseases (COPD) and middle ear infection (otitis media), according to a study by researchers at Georgia State University. The findings, published in the online journal Scientific Reports, identify a novel mechanism that resveratrol, a compound found naturally in some plant foods such as grapes, uses to alleviate inflammation in airway disease.
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