Nearly 1 in 3 drugs found to have safety concerns after FDA approval
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- Category: Research
How often are safety concerns raised about a drug after it's been approved by the FDA? Nicholas Downing, MD, of the Department of Medicine at Brigham and Women's Hospital, and colleagues have found that for drugs approved between 2001 and 2010, nearly 1 in 3 had a postmarket safety event. The team defines postmarket safety events as those that lead to either withdrawal from the market due to safety concerns, a boxed warning or FDA issuance of a safety communication.
High levels of exercise linked to nine years of less aging at the cellular level
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Despite their best efforts, no scientist has ever come close to stopping humans from aging. Even anti-aging creams can't stop Old Father Time. But new research from Brigham Young University reveals you may be able to slow one type of aging - the kind that happens inside your cells. As long as you're willing to sweat.
Public skeptical of research if tied to a company
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When it comes to research warning us about the latest health risks or touting the latest cure, a new Michigan State University study indicates that many people won't trust the findings when an industry partner, even with a good reputation, is involved. The study, published in PLoS One, could present scientists with the additional dilemma of finding alternative funding sources, especially during a time when federal funding may be scarce, that won't jeopardize the perceived integrity of their research.
Vitamin A deficiency is detrimental to blood stem cells
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- Category: Research
Many specialized cells, such as in the skin, gut or blood, have a lifespan of only a few days. Therefore, steady replenishment of these cells is indispensable. They arise from so-called "adult" stem cells that divide continuously. In addition, there is a group of very special stem cells in the bone marrow that were first discovered in 2008 by a research team led by Andreas Trumpp, who is a division head at the DKFZ and director of HI-STEM.
Researchers identify 6,500 genes that are expressed differently in men and women
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Men and women differ in obvious and less obvious ways - for example, in the prevalence of certain diseases or reactions to drugs. How are these connected to one's sex? Weizmann Institute of Science researchers recently uncovered thousands of human genes that are expressed - copied out to make proteins - differently in the two sexes.
Antibiotic doxycycline may offer hope for treatment of Parkinson's disease
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A study published in the journal Scientific Reports suggests that doxycycline, an antibiotic used for over half a century against bacterial infections, can be prescribed at lower doses for the treatment of Parkinson's disease. According to the authors, the substance reduces the toxicity of α-synuclein, a protein that, under certain conditions, forms abnormal accumulations of aggregates in central nervous system cells, which are damaged as a result.
Pathways leading to beta cell division identified, may aid diabetes treatment
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- Category: Research
Pancreatic beta cells help maintain normal blood glucose levels by producing the hormone insulin - the master regulator of energy (glucose). Impairment and the loss of beta cells interrupts insulin production, leading to type 1 and 2 diabetes. Using single-cell RNA sequencing, researchers at University of California San Diego School of Medicine have, for the first time, mapped out pathways that regulate beta cell growth that could be exploited to trick them to regenerate.
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