Study yields more than a million new cyclic compounds, some with pharmaceutical potential
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Researchers say they can now produce a vast library of unique cyclic compounds, some with the capacity to interrupt specific protein-protein interactions that play a role in disease. The new compounds have cyclic structures that give them stability and enhance their ability to bind to their targets.
Fiber-fermenting bacteria improve health of type 2 diabetes patients
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The fight against type 2 diabetes may soon improve thanks to a pioneering high-fiber diet study led by a Rutgers University-New Brunswick professor. Promotion of a select group of gut bacteria by a diet high in diverse fibers led to better blood glucose control, greater weight loss and better lipid levels in people with type 2 diabetes, according to research published today in Science.
Surprise finding could lead to new MS treatments
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A surprise finding by medical scientists may lead to the development of a possible treatment for multiple sclerosis (MS). While examining human brain tissues, researchers from the University of Alberta and McGill University unexpectedly found that the tissues from people who had MS contained an extremely high level of a protein named calnexin, compared with those who hadn't had MS.
Many clinical trial status discrepancies identified between ClinicalTrials.gov and EUCTR
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Approximately one sixth of clinical trials registered on both ClinicalTrials.gov and the EU Clinical Trials Register (EUCTR) have discrepancies in their completion status, according to a study published March 7, 2018 in the open-access journal PLOS ONE by Jessica Fleminger and Ben Goldacre from the University of Oxford, UK.
Drug-producing bacteria possible with synthetic biology breakthrough
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Bacteria could be programmed to efficiently produce drugs, thanks to breakthrough research into synthetic biology using engineering principles, from the University of Warwick and the University of Surrey. Led by the Warwick Integrative Synthetic Biology Centre at Warwick's School of Engineering and the Faculty of Health and Medical Sciences at the University of Surrey, new research has discovered how to dynamically manage the allocation of essential resources inside engineered cells -
Potential new approach to the treatment of multiple sclerosis
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A prospective new method of treating patients with multiple sclerosis has been proposed by researchers of the Mainz University Medical Center working in cooperation with researchers of the University of Montreal. In model trials and experiments employing human endothelial cells, they discovered that the EGFL7 protein hinders the migration of immune cells into the central nervous system by stabilizing the blood-brain barrier.
Unique pancreatic stem cells have potential to regenerate beta cells, respond to glucose
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Scientists from the Diabetes Research Institute at the University of Miami Miller School of Medicine have confirmed the existence of progenitor cells within the human pancreas that can be stimulated to develop into glucose-responsive beta cells. These significant findings, published in Cell Reports, open the door to developing regenerative cell therapies for those living with type 1 diabetes, addressing a major challenge that stands in the way of discovering a biological cure for the disease.
More Pharma News ...
- New research looks to reduce side effects in commonly used drugs
- New link between gut bacteria and obesity
- Fertility study finds hormone that could support early pregnancy
- Study weighs risks and benefits of phase I trials in pediatric cancer
- Calcium may play a role in the development of Parkinson's disease
- Women who clean at home or work face increased lung function decline
- Researchers find existing drug effective at preventing onset of type 1 diabetes