The preclinical study, published in Cardiovascular Diabetology, found LXA4, which is known for its "calming agent" action in turning off the body’s inflammatory response and preventing chronic inflammation, could also serve as a potential new treatment for diabetes-induced heart disease.

Heart conditions like atherosclerosis, heart attacks and heart failure are the leading killers of people with diabetes, driving a growing global health crisis.

Researchers at Karolinska Institutet have found a molecule that can both help the intestines to heal after damage and suppress tumour growth in colorectal cancer. The discovery could lead to new treatments for inflammatory bowel disease (IBD) and cancer. The results are published in the journal Nature.

Many patients with inflammatory bowel disease (IBD) such as Crohn's disease or ulcerative colitis do not respond to available treatments, highlighting the need to identify novel therapeutic strategies.

Malaria, particularly in its severe forms, remains a global health and economic burden. It causes the deaths of more than 600,000 people every year - most of them African children under five. In a new study, published in the journal Nature, researchers from EMBL Barcelona, the University of Texas, the University of Copenhagen, and The Scripps Research Institute have discovered human antibodies that can recognise and target some of the proteins that cause severe malaria. This breakthrough could pave the way for future vaccines or anti-malaria treatments.

Researchers at the Schulich Faculty of Chemistry at the Technion have developed a new chemical process to produce raw materials for the manufacture of polymers, pharmaceuticals, and agricultural compounds. In a paper about the process in Nature Chemistry, the researchers detail how they developed the new process and conducted a computational analysis to explain its mechanisms and key stages. The study was led by doctoral students Alexander Koronatov and Deepak Ranolia, and postdoctoral researcher Pavel Sakharov, under the guidance of Prof. Mark Gandelman.

A multitude of genes have been linked to the development of Alzheimer's disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box though, in part because of the challenges of examining in molecular detail the brain of a living patient.

Using cerebrospinal fluid (CSF) collected from living patients, a team of researchers at Washington University School of Medicine in St. Louis has for the first time linked disease-related proteins and genes to identify specific cellular pathways responsible for Alzheimer's genesis and progression.

Scientists at the University of Copenhagen have discovered a new weight loss drug target that reduces appetite, increases energy expenditure, and improves insulin sensitivity without causing nausea or loss of muscle mass. The discovery was reported in the journal Nature and could lead to a new therapy for millions of people with both obesity and type 2 diabetes who do not respond well to current treatments.

Millions of people around the world benefit from weight loss drugs based on the incretin hormone GLP-1.

Immune cells are capable of detecting infections just like a sniffer dog, using special sensors known as Toll-like receptors, or TLRs for short. But what signals activate TLRs, and what is the relationship between the scale and nature of this activation and the substance being detected? In a recent study, researchers from the University of Bonn and the University Hospital Bonn (UKB) used an innovative method to answer these questions. The approach that they took might help to speed up the search for drugs to combat infectious diseases, cancer, diabetes or dementia.