Breaking WORLD PHARMA NEWS

Study points out that a synthetic molecule helps reduce visceral fat and improve sleep

A study conducted by researchers from the Pennington Biomedical Research Center (PBRC, United States), Proteimax Biotechnology (Israel), and the University of São Paulo’s Biomedical Sciences Institute (ICB-USP, Brazil) showed that ingesting Pep19 helps reduce visceral fat and improve sleep in obese adults. The molecule is a synthetic version of a peptide (a very small piece of protein) naturally found in human cells.

Read more …

New research makes first broad-spectrum antiviral

Researchers at the Nanoscience Initiative at the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have made a breakthrough in the fight against viral diseases. Their study, published in the journal Science Advances, offers a promising path toward the development of the world’s first broad-spectrum antiviral (BSA), which could be deployed against a wide range of deadly viruses, including future pandemic threats.

Read more …

Ultrasound could deliver drugs with fewer side effects

The trouble with many drugs is that they go where they shouldn’t, producing unwanted side effects. Psychiatric drugs might cause dissociation, painkillers can induce nausea and chemotherapy often damages healthy cells. Now a team of Stanford Medicine researchers are closing in on a novel solution: a non-invasive system that can deliver drugs anywhere in the body with precision down to a few millimeters.

Read more …

Nature could be an effective self-help tool for improving mental health

Engaging with nature could be an effective measure for those with low wellbeing to reduce symptoms of depression and anxiety.

A new pilot study from the University of Exeter, published in Behavioral Sciences, found that a self-guided, four-week nature-based programme called Roots and Shoots could help adults boost their mood, enhance mindfulness, and reconnect with the natural environment.

Read more …

Vaccines trigger rapid lymph node responses

Vaccines trigger a notably rapid response in the stromal cells of draining lymph nodes within the first hours after administration. Researchers at the University of Turku and the InFLAMES Flagship in Finland also discovered that the stromal alterations prime the lymph node landscape for the subsequent steps of vaccine-induced immune responses.

Lymph nodes are a key part of the human immune system, whose primary function is to combat infections.

Read more …

Moffitt study finds promising new combo therapy for drug-resistant melanoma

A new study from Moffitt Cancer Center may offer a breakthrough for patients with advanced melanoma who don’t respond to current immunotherapy treatments. The research, published in the Journal for ImmunoTherapy of Cancer, found that adding a third immune-targeting drug to existing therapies helped shrink tumors in lab models of treatment-resistant melanoma.

Immunotherapy works by activating the body’s own immune system to attack cancer.

Read more …

Mitochondrial antioxidant found to drive breast cancer metastasis

The mitochondria may be the powerhouse of the cell, but mounting evidence suggests this organelle is also a driving force behind cancer. Now, new evidence points to the mitochondrial metabolite glutathione, highlighting its central role in helping breast cancer cells break away from the primary tumor, travel through the body, and take root in other tissues.

The findings are among the first to link a specific mitochondrial metabolite to metastasis, with strong implications for the study of cancer at the cellular level.

Read more …

Phase I/II clinical study of gene therapy for GM2 gangliosidosis, including Tay-Sachs and Sandhoff diseases, shows encouraging results

Patients in a Phase I/II clinical trial conducted by UMass Chan Medical School of a dual vector gene therapy for GM2 gangliosidosis, which includes Tay-Sachs and Sandhoff diseases, exhibited a biochemical correction of the disease with minimal adverse reactions.

"Biochemically it worked," said study investigator Heather Gray-Edwards, DVM, PhD, assistant professor of genetic & cellular medicine at UMass Chan.

Read more …

New discovery could lower heart attack and stroke risk for people with type 2 diabetes

New research from the Charles Perkins Centre at the University of Sydney has uncovered a new biological pathway that may help explain why people with type 2 diabetes are more prone to developing dangerous blood clots, potentially paving the way for future treatments that reduce their cardiovascular risk.

The study, led by Associate Professor Freda Passam from the Central Clinical School and Associate Professor Mark Larance from the School of Medical Sciences, was published in the Journal of Clinical Investigation.

Read more …

ADAMTS2: A multifunctional protein with therapeutic potential

ADAMTS2, a member of the ADAMTS zinc metalloproteinase family, is widely recognized for its pivotal role as a procollagen I N-proteinase. This enzyme plays a crucial part in the maturation of fibrillar collagens, which are essential for maintaining the structural integrity of connective tissues. Beyond its traditional role, recent discoveries have revealed that ADAMTS2 is involved in a diverse range of biological processes that extend well beyond collagen maturation.

Read more …