Breaking WORLD PHARMA NEWS

Make - your - own weight - loss drug using an innovative genome editing approach

Weight-loss drugs have surged in popularity, promising rapid results with regular injections. Now, researchers from Japan report a way for the body to make its own weight - loss drugs, doing away with injections in favor of a one - time treatment.

In a study published in Communications Medicine, researchers from The University of Osaka have revealed that a modified genome editing approach to tackle noncommunicable, multifaceted diseases.

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Common autoimmune drug may help reverse immunotherapy - induced diabetes

A team of researchers at the UCLA Health Jonsson Comprehensive Cancer Center has identified a potential new strategy to prevent, and even reverse, immune checkpoint inhibitor - induced type 1 diabetes, a rare but life-threatening side effect of cancer immunotherapy, using an existing class of autoimmune drugs.

The study, published in JCI Insight, identifies a new group of immune cells involved in the development immune checkpoint inhibitor - induced type 1 diabetes and shows that JAK inhibitors,

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Cohort data from Denmark show real-world evidence of stable protection against HPV-related cervical cancer

Among the more than 100 types of human papillomavirus (HPV), at least 14 are considered as 'high-risk' types which can cause (cervical) cancer. After breast cancer, cervical cancer is the most common cancer in Europe among women aged 15 - 44 years [1].

Before HPV vaccination among teenage girls started in Denmark, high-risk HPV was found in all cervical cancers. HPV types 16/18 accounted for around three quarters (74%) of cervical cancers.

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Researchers discover new way cells protect themselves from damage

An international team led by researchers at The Hospital for Sick Children (SickKids), Princess Margaret Cancer Centre, Dalhousie University, the University of Exeter (UK) and the Medical University of Vienna (Austria) has uncovered a surprising way compartments within cells work together to defend themselves against oxidative stress, a finding that could shift how we understand age-associated conditions such as diabetes and neurodegenerative diseases.

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Nerve pain drug gabapentin linked to increased dementia, cognitive impairment risks

Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI) - 29% and 85%, respectively - finds a large medical records study published online in the journal Regional Anesthesia & Pain Medicine.

What's more, these risks were more than twice as high in those normally considered too young to develop either condition - 18 - 64 year olds - the findings indicate.

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Researchers develop potent CDK9 inhibitor to overcome drug resistance in hematological malignancies

A research team led by Prof. LIU Qingsong and Prof. LIU Jing from the Hefei Institutes of Physical Science, Chinese Academy of Sciences, has recently developed a new class of compounds that effectively inhibit both wild-type CDK9 and its drug-resistant mutant form, offering a promising strategy for treating hematological malignancies.

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Research opens up new avenue for tuberculosis drug discovery

A new study by University of Bath scientists has highlighted two new potential families of drug molecules that could open the door to new treatments for tuberculosis.

Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, is the second largest infectious killer globally after COVID-19 and causes 1.3 million deaths annually.

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Aggressive skin cancer driven by mitochondrial processes - existing drugs offer promising treatment path

A new study led by researchers at Lund University in Sweden, reveals that melanoma, the deadliest form of skin cancer, can in some cases be driven by mitochondrial processes, which can be effectively targeted using existing drugs. In preclinical laboratory experiments with melanoma cell cultures, researchers successfully eliminated cancer cells by using antibiotics and inhibitors of mitochondrial energy production, highlighting a potential therapeutic breakthrough.

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Study highlights major hurdles for multinational clinical trials in Europe

A new study by investigators from Europe, including the Netherlands and the United Kingdom (UK), has shed light on significant ethical, administrative, regulatory, and logistical (EARL) hurdles in delivering multinational randomized clinical trials. The research was the first to comprehensively quantify these barriers for an international platform trial and emphasizes the need for urgent improvements, particularly in preparing for future public health crises.

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New model to find treatments for an aggressive blood cancer

Researchers working on an incurable blood cancer can now use a new lab model which could make testing potential new treatments and diagnostics easier and quicker, new research has found.

In a paper published in Nature Communications a team of researchers led from the University of Birmingham have studied blood cells from patients with a blood cancer called myelodysplastic syndrome disease (MDS).

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