Experimental chemo drug may trick the immune system into fighting cancer
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A new discovery from researchers at The University of Texas at Austin and The University of Texas MD Anderson Cancer Center helps explain why some chemotherapy drugs not only eliminate cancer cells directly, they - at least in some patients - actually trigger the innate immune system to attack cancer cells.
The researchers made this discovery while testing a potential chemotherapy agent referred to as Compound 1 - which causes a build-up of toxic molecules called reactive oxygen species - on preclinical models.
New drug combination doubles down on Alzheimer's treatments
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A new study finds that combining the current medications for Alzheimer’s disease with small molecules derived from micronutrients found in grapes, berries, peanuts and turmeric is a safer and more effective way to treat the disease.
Individuals with Alzheimer’s have a buildup of toxic amyloid proteins in the brain. Researchers from the School of Pharmacy at the University of Waterloo combined amyloid-destroying small molecules with anti-amyloid antibodies that are already used in Alzheimer’s treatment.
Life-changing drug identified for children with rare epilepsy
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A new experimental treatment for children with a hard-to-treat form of epilepsy is safe and can reduce seizures dramatically, helping them lead much healthier and happier lives, the findings of a UCL (University College London) and Great Ormond Street Hospital-led international clinical trial show.
In a new paper published in The New England Journal of Medicine, the researchers found that children with Dravet syndrome had up to 91 per cent fewer seizures while being regularly administered a new medication called zorevunersen.
People with COPD commonly misuse medications
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Medication nonadherence among people with chronic obstructive pulmonary disease (COPD) is a result of affordability and lack of knowledge about medications, among other factors, and leads to increased exacerbations and faster lung function decline, according to two new studies. The studies are published in the January 2026 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open access journal.
Chemically ‘stapled’ peptides used to target difficult-to-treat cancers
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Researchers at the University of Bath have developed a new technology that uses bacteria to build, chemically stabilise, and test millions of potential drug molecules inside living cells, making it much quicker and easier to discover new treatments for difficult-to-treat cancers.
New study identifies growth hormone receptor as possible target to improve lung cancer treatment
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Researchers at Ohio University have discovered what may be a new way to fight lung cancer that is resistant to other treatments. The study published in the International Journal of Molecular Science and led by Goll-Ohio Eminent Scholar and distinguished professor John J. Kopchick, Ph.D., and his graduate student Arshad Ahmad at the Heritage College of Osteopathic Medicine, found that blocking the growth hormone receptor may help make lung cancer treatments more effective.
A highly precise target for medications against tropical diseases
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Cells have to break down sugar to produce energy. In most organisms, this process of glycolysis takes place in the cytosol. This is not the case with trypanosomes. These possess specialized organelles called glycosomes where glycolysis takes place. “Because the parasites rely fundamentally on these organelles for energy production, any disruption of glycosome biogenesis is lethal to them,” says Erdmann.
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